Home  >  Products  >  ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADAMTS-2, ADMP-1, Aggrecanase-1, KIAA0688, UNQ769/PRO1563)
ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADAMTS-2, ADMP-1, Aggrecanase-1, KIAA0688, UNQ769/PRO1563)

ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADAMTS-2, ADMP-1, Aggrecanase-1, KIAA0688, UNQ769/PRO1563)

Cat no: A0859-60V

Supplier: United States Biological
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ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 2.6ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human heart Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0859-60V
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4, EC=3.4.24.82
Additional info: Recognizes human ADAMTS4.

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