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ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, Aggrecanase-1)

ADAMTS4 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, Aggrecanase-1)

Cat no: A0859-60N

Supplier: United States Biological
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ADAMTS4 is a human gene that encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (adisintegrin and metalloprotease) family members based on the multiple copies of thrombospondin 1-like repeats they carry. Pratta et al. (2003) concluded that ADAMTS4 is constitutively produced in monolayer chondrocytes, capsular fibroblasts, and cartilage, and that stimulation by interleukin-1 results in aggrecanase activation. Thus, the activator could be a potential target by which to control aggrecanase-mediated degradation in arthritic diseases. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot:1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0859-60N
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Tang BL, Hong W (1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.". FEBS Lett. 445 (2-3): 223
Additional info: Recognizes mouse ADAMTS4. Species Cross-Reactivity: rat.

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