Home  >  Products  >  ADAMTSL-1 (Punctin-1, ADAMTS-like protein 1 precursor, ADAMTSR1, C9orf94, DKFZp686L03130, FLJ35283, FLJ41032, FLJ46891, MGC118803, MGC118805, MGC40193, UNQ528/PRO1071)
ADAMTSL-1 (Punctin-1, ADAMTS-like protein 1 precursor, ADAMTSR1, C9orf94, DKFZp686L03130, FLJ35283, FLJ41032, FLJ46891, MGC118803, MGC118805, MGC40193, UNQ528/PRO1071)

ADAMTSL-1 (Punctin-1, ADAMTS-like protein 1 precursor, ADAMTSR1, C9orf94, DKFZp686L03130, FLJ35283, FLJ41032, FLJ46891, MGC118803, MGC118805, MGC40193, UNQ528/PRO1071)

Cat no: A0859-62B

Supplier: United States Biological
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Punctin-1 is a secreted molecule resembling members of the family of proteases designated ADAMTS (a disintegrin-like and metalloprotease domain with thrombospondin type I motif). ADAMTS proteases are secreted enzymes that consist of a metalloprotease domain (which provides the catalytic activity) and ancillary domains (which provide substrate, cell or extracellular matrix activity). Punctin-1 lacks the pro-metalloprotease and the disintegrin-like domain typical of this family but contains other ADAMTS domains in precise order including 4 thrombospondin-I repeats. Punctin-1 is an extracellular matrix protein in tissues and deposited into the cell substratum and localized towards the periphery of transfected cells. Punctin-1 and Punctin-2 (ADAMTSL-3) are the first members of a novel family of ADAMTS-like proteins that appear to have important functions in the extracellular matrix. Applications: Suitable for use in Western Blot and Immunoassays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0859-62B
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
Alternative names: ADAMTSL-1
References: 1. Hirohata, S et al; Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem 2002, 277: 12182
Additional info: Recognizes the first thrombospondin repeat near the N-terminal and reacts with molecular species of 55kD or a doublet of 55kD and 60kD (glycosylated form). Note that proteolysis of Punctin-1 has been described and additional smaller bands may also be obtained.

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