Adiponectin (rat) BioAssay(TM) ELISA Kit (ACRP30, AdipoQ, apM1, GBP28, Adipocyte complement related protein of 30kD)

Adiponectin is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium).\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C

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SPECIFICATIONS

Catalog Number

044471

Size

96Tests

References

Product Reference: \n?A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells: E. Sonoda, et al.; Endocrinology 149, 4794 (2008)\n?The Lou/C rat: A model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue: C. Veyrat-Durebex, et al.; Am. J. Physiol. Endocrinol. Metab. 296, E1120 (2009)\n?Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats: Y. Ando, et al.; Inflamm. Bowel Dis. 14, 826 (2008)\n?Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis: Y. Haddad, et al.; Evid. Based Compl. Alternat. Med. (Epub ahead of print), (2009)\n?Effects of aerobic exercise training on visceral fat and serum adiponectin concentration in ovariectomized rats: A. Damirchi, et al.; Climacteric 13, 171 (2010)\n?Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture: K. Udo, et al.; Kidney Int. 78, 60 (2010)\n?The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats: Y.C. Tsai, et al.; Menopause 17, 1194 (2010)\n?Effects of ovariectomy and estrogen replacement therapy on visceral adipose tissue and serum adiponectin levels in rats: P. Babaei, et al.; Menopause Int. 16, 100 (2010)\n?High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations: C. de Oliveira, et al.; Lipids Health Dis. 10, 11 (2011)\n?Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways: A. Meeprom, et al.; Br. J. Nutr. 106, 1173 (2011)\n?Effects of adrenal hormones on the expression of adiponectin and adiponectin receptors in adipose tissue, muscle and liver: C. de Oliveira, et al.; Steroids 76, 1260 (2011)\n?Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats: S.K. Ha, et al.; J. Comp. Pathol. 145, 88 (2011)\n?N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats: T. Wang, et al.; PLoS One 6, e23967 (2011)\n?NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA: Y. Haddad, et al.; Int. J. Hepatol. 2011, 136816 (2011)\n?Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet: M.A. Lukaszewski, et al.; AJPEM 301, E548 (2011)\n?

Additional Info

Detects rat adiponectin. Does not cross-react with mouse adiponectin, human adiponectin, rat resistin, rat RELM-alpha or rat leptin.

Alternative Names

ACRP30, AdipoQ, apM1, GBP28, Adipocyte complement related protein of 30kDa