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Adiponectin Receptor 1 (AdipoR1, CGI-45)

Cat no: A0886-75

Adiponectin Receptor 1 (AdipoR1, CGI-45)

The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha (PPARA) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ADIPOR1 and ADIPOR2 are highly related structurally, and mouse Adipor1 and Adipor2 share 66.7% identity. ADIPOR1 and ADIPOR2 are 7-transmembrane domain proteins, but they are structurally, topologically, and functionally distinct from G proteincoupled receptors (GPCRs). The mouse, human, and rat Adipor1 protein (ADIPOR1) contains 375 amino acids (with a predicted MW of 42.4 kD). Human and mouse ADIPOR1 have 96.8% homology. ADIPOR1 has high-affinity receptor for globular adiponectin (gACRP30) but low-affinity receptor for full-length adiponectin. ADIPOR1 is widely expressed. It is highly expressed in skeletal muscle. It is expressed at intermediate levels in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. It is weakly expressed in colon, thymus and small intestine.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000\nImmunohistochemistry (paraffin sections): 1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A0886-75

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid.

P Type

Pab

Purity

Neat serum

Isotype

IgG

References

1. Yamauchi, T., et al., Nature 423: 762 (2003).

Additional Info

Recognizes human AdipoR1.

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