ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.
Biological Activity:
Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells.
Sequence:
Rat adiponectin (aa 16-244) is fused at the N-terminus to a FLAG(R)-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Working aliquots are stable for up to 3 months when stored at -20 degrees C.