ADRA2A (Adrenergic, alpha-2A-, Receptor, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, OTTHUMP00000058849, Alpha-2A-Adrenergic Receptor, Alpha-2AAR Subtype C10)

Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins. Alpha 2C has a wide distribution pattern in the CNS. On neurons alpha 2 adrenergic receptors are located on both pre- and postsynaptic domains where they mediate an inhibitory role in the central and peripheral nervous system. Alpha 2C has a wide distribution pattern in the CNS. At the spinal cord level the vast majority of alpha 2C is not of primary afferent origin; however, a small fraction of neurons in DRG do express mRNA for alpha 2C and harbor the protein. Colocalization has been observed between alpha 2C and enkephalin in the spinal cord dorsal horn, suggesting that alpha 2C may be expressed by a subset of spinal interneurons. The distribution pattern of alpha 2C suggests functions at several levels in the brain. Antibody showed positive staining in rat spinal cord dorsal horn, ventral horn motor neurons and retina. When examined in other brain regions known to express alpha 2A staining was not observed.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A0906-64A

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum, Mouse, Rat, Can

Form

Supplied as a liquid in 0.5 mg/ml tris-saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Park L, Nigg JT, Waldman ID, Nummy KA, Huang-Pollock C, Rappley M, Friderici KH. Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD. Mol Psychiatry. 2005 Jun;10(6):572-80.

Additional Info

Recognizes human ADRA2A. Species Crossreactivity: Canine, mouse and rat.