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Adrenergic Receptor, Alpha 2c

Adrenergic Receptor, Alpha 2c

Cat no: A0906-80B

Supplier: United States Biological
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Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins. Alpha 2C has a wide distribution pattern in the CNS. On neurons Alpha 2 adrenergic receptors are located on both pre- and postsynaptic domains where they mediate an inhibitory role in the central and peripheral nervous system. Alpha 2C has a wide distribution pattern in the CNS. At the spinal cord level the vast majority of alpha 2C is not of primary afferent origin; however, a small fraction of neurons in DRG do express mRNA for alpha 2C and harbor the protein. Colocalization has been observed between alpha 2C and enkephalin in the spinal cord dorsal horn, suggesting that alpha 2C may be expressed by a subset of spinal interneurons. The distribution pattern of alpha 2C suggests functions at several levels in the brain. Antibody showed positive staining in rat spinal cord dorsal horn, ventral horn motor neurons and retina. When examined in other brain regions known to express a2A staining was not observed. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:200-1:500 Immunocytochemistry: 1:200-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0906-80B
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 50ul
Form: Supplied as a liquid.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Stone, L.S., Broberger, C., Vulchanova, L., Wilcox, G.L., Hokfelt, T., Riedl, m. S., and Elde, R. (1998). Differential distribution of alpha 2A and alpha 2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci 18, 5928-37. Lanier, S.M., Downing, S., Duzic, E., Homcy, C.J. (1991). Isolation of rat genomic clones encoding subtypes o alpha 2adrenergic recepor: identification of a unique receptor subtype. J Biol Chem 266, 10470-10478. f - t
Additional info: Recognizes human and rat Adrenergic Receptor, Alpha 2c.

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