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Adrenergic Receptor, Alpha 2c

Adrenergic Receptor, Alpha 2c

Cat no: A0906-80C

Supplier: United States Biological
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The alpha-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. There are 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha2C is required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. Positive Control: Human brain lysate and rat ventral spinal cord Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0906-80C
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, Alpha2-AR-C4, Alpha-2-adrenergic receptor, renal type, adrenergic, alpha-2C-, receptor, alpha-2C-adrenergic receptor
References: 1. Eason, M. G. and Liggett, S. B. Human alpha-2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha-2-C10, alpha-2-C4, and alpha-2-C2 mRNA in multiple tissues. Molec. Pharm. 44: 70-75, 1993 2. Hein, L., Altman, J. D. and Kobilka, B. K. Two functionally distinct alpha-2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402: 181-184, 1999. 3. Regan, J. W., Kobilka, T. S., Yang-Feng, T. L., Caron, M. G., Lefkowitz, R. J. and Kobilka, B. K. Cloning and expression of a human kidney cDNA for an alpha-2-adrenergic receptor subtype. Proc. Nat. Acad. Sci. 85: 6301-6305, 1988.
Additional info: Recognizes human Adrenergic Receptor, alpha 2c.

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