Aflatoxin B1

Aflatoxin is a naturally occurring mycotoxin produced by two types of mold: Aspergillus flavus and Aspergillus parasiticus. Aspergillus flavus is common and widespread in nature and is most often found when certain grains are grown under stressful conditions such as drought. At least 13 different types of aflatoxin are produced in nature with aflatoxin B1 considered as the most toxic. Aflatoxin B1 exposure may be a potential etiological agent in hepatocellular carcinoma.\n\nApplications: \nSuitable for use in Immunofluorescence, ELISA and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunocytochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nCellular Localization: Nuclear\n\nPositive Control: human HepG2 liver samples\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A0924-01D

Size

100ul

Applications

ELISA, ICC, IF

Hosts

Mouse

Form

Supplied as a liquid containing sodium azide

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. Chen, CJ, et al. Aflatoxin B1 DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma. Hepatology. 16(5): 1150-1155 (1992) [uses this clone] 2. Zhang, YJ, et al. Aflatoxin B1 DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and non-tumorous liver tissue. Carcinogenesis. 12(12): 2247-2252 (1991) [uses this clone]

Additional Info

Recognizes Aflatoxin B1. Species Crossreactivity: All species. There is no crossreactivity with other carcinogen-DNA adducts.

Alternative Names

AFB1, AFB1-AR, Aldoketoreductase 7