Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo.
Chemical Name: N-benzyl-3,4-dihydroxybenzylidenecyanoacetamide
Chemical Family: Aromatic nitrile
Melting Point:
218-220 degrees C
Solubility:
Acetone, Chloroform, Ethanol, Methanol
Method for Determining Identitiy:
H NMR Spectroscopic Analysis
TLC Conditions:
SiO2; Hexane: Ethyl Acetate; 2:1; Visualized with AMCS;
Single Spot; Rf=0.25.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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