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AG 490 (Tyrphostin B42, N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide)

Cat no: A0928-65


Supplier: United States Biological
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Specific and potent JAK2 protein tyrosine kinase inhibitor. Also, inhibits EGF receptor autophosphorylation, with IC50 of 100nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Blocks growth of leukemic cells in vitro and in vivo. Chemical Name: N-benzyl-3,4-dihydroxybenzylidenecyanoacetamide Chemical Family: Aromatic nitrile Melting Point: 218-220 degrees C Solubility: Acetone, Chloroform, Ethanol, Methanol Method for Determining Identitiy: H NMR Spectroscopic Analysis TLC Conditions: SiO2; Hexane: Ethyl Acetate; 2:1; Visualized with AMCS; Single Spot; Rf=0.25. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: A0928-65
Size: 25mg
Form: Supplied as a brownish yellow solid.
Purity: ~98%
Alternative names: Tyrphostin B42

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