AGPAT6 (1-acyl-sn-glycerol-3-phosphate acyltransferase zeta, Testis spermatogenesis apoptosis-related protein 7, EC=2.3.1.51, 1-AGP acyltransferase 6, 1-AGPAT 6, Lysophosphatidic acid acyltransferase-zeta, LPAAT-zeta)

AGPAT6 is a novel glycerolipid acyltransferase of the ER, which is crucial for the production of milk fat by the mammary gland.\nAgpat6 deficient mice exhibit a 25% reduction in body weight and resistance to both diet-induced and genetically induced obesity. The reduced body weight is associated with increased energy expenditure, reduced triglyceride accumulation in BAT and WAT, reduced white adipocyte size, and lack of adipose tissue in the subdermal region. AGPAT6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family. (1)\n\nCellular Localization: Membrane\n\nPositive Control: Mouse skeletal muscle lysate\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1059-59D

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

P Type

Pab

Purity

Purified by peptide immunoaffinity chromatography.

References

1. Beigneux, AP, et al. J. Lipid Res. 47: 734-744 (2006) 2. Vergnes, L., et al. J. Lipid Res. 47: 745-754 (2006)

Additional Info

This antibody is specific for AGPAT6. Species Crossreactivity: Human and mouse. Other species not tested.

Alternative Names

1-acyl-sn-glycerol-3-phosphate acyltransferase zeta, Testis spermatogenesis apoptosis-related protein 7, EC=2.3.1.51, 1-AGP acyltransferase 6, 1-AGPAT 6, Lysophosphatidic acid acyltransferase-zeta, LPAAT-zeta