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Ah Receptor (Aryl Hydrocarbon Receptor, AHR)

Ah Receptor (Aryl Hydrocarbon Receptor, AHR)

Cat no: A1059-72Y

Supplier: United States Biological
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The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor. Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1. Applications: Suitable for use in Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 1:100. Staining of rat liver results in strong cytoplasmic and some nuclear staining. Immunoprecipitation: A single ~95kD protein representing AHR from Hepa 1 cytosol. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1059-72Y
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation
Size: 100ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG
Purity: Ascites
Alternative names: Dioxin Receptor
References: Delescluse C et al. Is CYP1A1 induction always related to AHR signaling pathway? Toxicology 153:73-82 (2000). Perdew GH et al. Production and characterization of monoclonal antibodies directed against the Ah receptor. Hybridoma 14:279-283 (1995). Chen HS & Perdew GH Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. J Biol Chem 269:27554-27558 (1994).
Additional info: Recognizes mouse Aryl Hydrocarbon Receptor (AHR). Species Crossreactivity: human and rat.

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