Ah Receptor (Aryl Hydrocarbon Receptor, AHR, Aromatic Hydrocarbon Receptor, BHLHE76, Class E Basic Helix-loop-helix Protein 76, HGNC:348)

Supplier:

United States Biological

Cat no: A1059-72C

Ah Receptor (Aryl Hydrocarbon Receptor, AHR, Aromatic Hydrocarbon Receptor, BHLHE76, Class E Basic Helix-loop-helix Protein 76, HGNC:348)

Aryl hydrocarbon receptor (AHR) is a 96kD ligand-activated transcription factor expressed in all tissues tested. AHR binds planar aromatic hydrocarbons and plays a role in regulating biological responses to them. It activates expression of xenobiotic chemical metabolising enzyme genes such as cytochrome P450. AHR is also involved in cell-cycle regulation and is thought to be involved in tissue maturation.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nImmunohistochemistry (paraffin): Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. 0.01M sodium citrate buffer, pH 6.0 is recommended. \nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nRespitory epithelium and bronchial smooth muscle\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A1059-72C

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.1% sodium azide.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

References

1. Puga, A. et al. (2002) Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem.-Biol. Interac. 141:117-130. 2. Dale, Y. et al. (2006) Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. Mol Pharmacol. 70:1481-1487.

Additional Info

Recognizes human AHR.

Alternative Names

Aryl Hydrocarbon Receptor Precursor

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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