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AHA1 (Activator of Hsp90 ATPase)

Cat no: 168010

AHA1 (Activator of Hsp90 ATPase)

Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist client-protein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa370

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SPECIFICATIONS

Catalog Number

168010

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Rat

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2a, k

Additional Info

Recognizes mouse AHA1. Species Crossreactivity: chimpanzee and human.

Alternative Names

Aha1, Ahsa1 antibody, Activator of Hsp90 ATPase, Activator of 90 kDa heat shock protein ATPase homolog 1 antibody

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