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AHSA2, Recombinant, Human (Activator of 90kD Heat Shock Protein ATPase Homolog 2, Aha2 Protein)

AHSA2, Recombinant, Human (Activator of 90kD Heat Shock Protein ATPase Homolog 2, Aha2 Protein)

Cat no: A1059-73Y

Supplier: United States Biological
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Aha2 shares 45% sequence homology with Aha1, however, little is known about the functional protein. Aha1 is a member of the Hsp90 cochaperone family, and is thought to stimulate Hsp90 ATPase activity by competing with p23 and other co-chaperones for Hsp90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/Hsp90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4). Source: Recombinant corresponding to human Aha2 at the N-terminal, fused to His-tag, expressed in E. coli (ENSG00000173209). Applications: Suitable for use Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1059-73Y
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in 10mM Tris, pH 4.5, 100mM NaH2PO4, 8M urea.
Purity: ~90% (SDS-PAGE)
References: 1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub, 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796, 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723, 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

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