AICAR (5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside)

Size

10mg

References

Product Reference: \n?5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?: J. M. Corton et al.; Eur. J. Biochem. 229, 558 (1995)\n?5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase: P. A, Lochhead et al.; Diabetes 49, 896 (2000)\n?The effects of AICAR on adipocyte differentiation of 3T3-L1 cells: S. A. Habinowski et al.; Biochem. Biophys. Res. Commun.286, 852 (2001)\n?5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved: J. M. Lopez et al.; Biochem. J. 370, 1027 (2003)\n?Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase: M. Bronner et al.; Biochem. J. 384, 295 (2004)\n?AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms: X. Xiang et al.; Biochem. Biophys. Res. Commun. 321, 161 (2004)\n?5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages: B. S. Jhun et al.; Biochem. Biophys. Res. Commun.318, 372 (2004)\n?The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism: S. H. Koo et al.; Nature 437, 1109 (2005)\n?5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase: S. Giri, et al.; J. Neurosci. 24, 479 (2004)\n?5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: I.P. Salt, et al.; Diabetes 49, 1649 (2000)\n?AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells: A.F. Santidrian, et al.; Blood 116, 3023 (2010)\n?AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation: C. Jose, et al.; Biochim. Biophys. Acta Epub ahead of print (2010)\n?Role of AMP-activated protein kinase in autophagy and proteasome function: R. Viana, et al.; BBRC 369, 964 (2008)\n?Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead: M. Meli, et al.; J. Med. Chem. 49, 7721 (2006)\n?