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AICDA, CT (Dr.92887, Aicda Protein)

AICDA, CT (Dr.92887, Aicda Protein)

Cat no: A0855-76

Supplier: United States Biological
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Activation-induced cytidine deaminase (AICDA) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination (CSR) in B cells, but inappropriate or dysregulated expression AICDA is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AICDA deaminates dC to dU residues in HIV cDNA as does APOBEC3G. In bony fish such as zebrafish, the AICDA homologue also showed a similar function with mammalians, in which AICDA protein can mediate CSR. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: A0855-76D Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0855-76
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Muramatsu M, et al (1999) J. Biol. Chem. 274:18470-6. 2. Muramatsu M, et al (2000) Cell. 102:553-63. 3. Greeve J, et al (2003) Blood. 101:3574-80. 4. Cascalho M (2004) J. Immunol. 172:6513-8. 5. Sheehy AM, et al (2002) Nature. 418:646-50. 6. Wakae, K., et al. (2006) Int. Immunol. 18(1): 41-47
Additional info: Recognizes zebrafish AICDA.

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