Apoptosis-inducing factor 1,Mouse,itochondrial (AIF) is an o, Xenopus/Amphibian,idoreductase that has a dual role in controlling cellular life and death. During apoptosis, AIF is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its o, Xenopus/Amphibian,idoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. AIF interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Defects in AIF are the cause of combined o, Xenopus/Amphibian,idative phosphorylation deficiency type 6 (CO, Xenopus/Amphibian,PD6). AIF is a mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, arefle, Xenopus/Amphibian,ia,Mouse,uscle weakness and wasting.
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