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AIRE (APECED, APS1, APSI, Autoimmune Regulator, PGA1, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein)

AIRE (APECED, APS1, APSI, Autoimmune Regulator, PGA1, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein)

Cat no: A1059-88A

Supplier: United States Biological
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This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000. Western Blot: 0.3-1ug/ml. ~ 55kDa band observed in Human Spleen lysates (calculated MW of 57.7kDa according to NP_000374.1). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A1059-88A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Niki S, Oshikawa K, Mouri Y, Hirota F, Matsushima A, Yano M, Han H, Bando Y, Izumi K, Matsumoto M, Nakayama KI, Kuroda N, Matsumoto M. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest. 2006 May;116(5):1292-301. Epub 2006 Apr 20. PMID: 16628255
Additional info: Species Crossreactivity: Human. Other species not tested.

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