AIRE (Autoimmune Regulator, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein Homolog, APECED Protein Homolog)

Supplier:

United States Biological

Cat no: A1059-88G

AIRE (Autoimmune Regulator, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein Homolog, APECED Protein Homolog)

AIRE (Autoimmune regulator; also APECED) is a 58-60kD transcriptional regulator that exhibits tight regulation of its expression. It is widely expressed in lymphoid organs, but is most pronounced in thymic medullary epithelium, where it induces the expression of organ-specific antigens that are used to sequester and delete autoreactive lymphocytes. Mouse AIRE is 552aa in length. It contains multiple domains, including an HSR domain with two LXXLL motifs (aa1-106), an NLS (aa114-134), one SAND domain (aa182-282) and two PHD zinc-finger regions (aa298-345; 434-475). AIRE will homodimerize and tetramerize. There are multiple potential isoforms that involve various combinations of deletions of aa265-268, 368-426 and Lys296, plus a 42aa substitution for aa368-552. Over aa476-552, mouse AIRE shares 91% and 65% aa identity with rat and human AIRE, respectively. \n\nApplications:\nSuitable for use in Western Blot Other applications not tested.\n\nRecommended Dilution:\nWestern Blot:1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1059-88G

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Mouse

Form

Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Recognizes mouse AIRE. Species sequence homology: human (65%), rat (91%).

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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