Home  >  Products  >  AKAP10 (A Kinase (PRKA) Anchor Protein 10, D-AKAP2, MGC9414, PRKA10, A-kinase Anchor Protein 10, Dual-specificity A-kinase Anchoring Protein 2, Mitochondrial A Kinase PPKA Anchor Protein 10, Protein Kinase A Anchoring Protein 10)
AKAP10 (A Kinase (PRKA) Anchor Protein 10, D-AKAP2, MGC9414, PRKA10, A-kinase Anchor Protein 10, Dual-specificity A-kinase Anchoring Protein 2, Mitochondrial A Kinase PPKA Anchor Protein 10, Protein Kinase A Anchoring Protein 10)

AKAP10 (A Kinase (PRKA) Anchor Protein 10, D-AKAP2, MGC9414, PRKA10, A-kinase Anchor Protein 10, Dual-specificity A-kinase Anchoring Protein 2, Mitochondrial A Kinase PPKA Anchor Protein 10, Protein Kinase A Anchoring Protein 10)

Cat no: A1102-83E

Supplier: United States Biological
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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.3-1microg/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A1102-83E
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Burns-Hamuro LL, Barraclough DM, Taylor SS. Identification and functional analysis of dual-specific A kinase-anchoring protein-2. Methods Enzymol. 2004;390:354-74.
Additional info: Recognizes human AKAP10 at ~74kD in Rat Brain lysates (calculated MW of 73.8kD according to human NP_009133.2 and according to Rat NP_001108078.1). Species Crossreactivity: Bovine, canine, mouse and rat.

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