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AKAP5, ID (AKAP5, AKAP79, A-kinase anchor protein 5, A-kinase anchor protein 79kD, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)

Cat no: 031734

AKAP5, ID (AKAP5, AKAP79, A-kinase anchor protein 5, A-kinase anchor protein 79kD, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

031734

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Willoughby, D., et al. J. Biol. Chem. 285(26):20328-20342(2010)\nChen, M.H., et al. Cell. Signal. 21(1):136-142(2009)\nTavalin, S.J. J. Biol. Chem. 283(17):11445-11452(2008)\nCorreia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)\nChai, S., et al. J. Biol. Chem. 282(31):22668-22677(2007)

Additional Info

Human

Alternative Names

AKAP5, AKAP79, A-kinase anchor protein 5, A-kinase anchor protein 79kD, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

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