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AKT, phosphorylated (Thr34) (Rac PKa, PKBa)

Cat no: A1124-01M

AKT, phosphorylated (Thr34) (Rac PKa, PKBa)

AKT, also known as Protein Kinase B (PKB) and Rac (Related to the A and C kinases), is a 60kDa serine/threonine kinase critical for controlling diverse cellular functions, including glucose metabolism, gene transcription, cell proliferation, and apoptosis. AKT phosphorylates a number of physiological substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. AKT is activated in response to insulin and growth factors in a PI3-kinase dependent manner. Activation of PI3-Kinase generates phosphatidylinositol 3,4-bisphosphate which may induce the membrane translocation of AKT coincident with its phosphorylation and activation. Upon activation, AKT associates with members of the PKC family of kinases, such as PKC

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SPECIFICATIONS

Catalog Number

A1124-01M

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Rat, Rabbit

Form

Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide, 50% gylcerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human AKT, phosphorylated at Thr34. Species Crossreactivity: rat, rabbit.

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