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Akt (Rac PKa, PKBa)

Akt (Rac PKa, PKBa)

Cat no: A1124-01D

Supplier: United States Biological
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The serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific. In the developing nervous system AKT is a critical mediator of growth factor induced neuronal survival. Survival factors can suppress apoptosis in a transcription independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene (referenced from entrez gene). Cellular Localization: Cytoplasmic and Nuclear Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A1124-01D
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug
Form: 0.02M K Phosphate, 0.15M NaCl, 0.01% Sodium Azide, pH7.2
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CAKT, Murine thymoma viral (vakt) oncogene homolog 1, PKB Akt, PKB alpha, PRKBA, RAC alpha serine/threonine protein kinase, RAC Serine/Threonine Protein Kinase, V AKT Murine Thymoma Viral Oncogene Homolog 1, VAKT Murine Thymona Viral Oncogene 1, RAC-PK-alpha, Protein kinase B
Additional info: Species Crossreactivity: Crossreacts with Human.

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