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AKT (Rac PKa, PKBa)

AKT (Rac PKa, PKBa)

Cat no: A1124-01P

Supplier: United States Biological
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The protein kinase B (PKB, also called AKT) family of protein kinases plays a key role in insulin signaling, cellular survival, and transformation. AKT1 is activated by phosphorylation on residues threonine 308 and Serine 473. Thr308, in the catalytic domain, is phosphorylated by the protein kinase PDK1, and Ser473, in the COOH-terminal regulatory domain, is phosphorylated by putative serine 473 kinase. To date, a couple of proteins have been shown to physically interact with PKB. Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Western Blot: 0.5-2ug/ml Immunoprecipitation: 3-5ug/extract Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1124-01P
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Maira, S. et al. Science 294, 374 (2002). 2. Hemmings, B. et al. Science 275, 628 (2001) 3. Stephens, L. et al. Science 279, 710 (1998). 4. Alessi, D. et al. Curr Biol 7, 261 (1997). 5. Bellacosa, A. et al. Science 254, 274 (1991). 6. Jones, P. et al. Proc Natl Acad Sci USA 88, 4171 (1991).
Additional info: Recognizes human AKT1. Species Crossreactivity: mouse and rat.

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