Akt Substrate, 160kD (AS160, DKFZp779C0666, KIAA0603, TBC1 domain family member 4, Rab GAP)

Supplier:

United States Biological

Cat no: A1124-53E

Akt Substrate, 160kD (AS160, DKFZp779C0666, KIAA0603, TBC1 domain family member 4, Rab GAP)

AS160 is a 160kD Akt substrate that plays a critical role in regulating insulin-stimulated exocytosis of glucose transporter GLUT4. AS160 contains a Rab GTPase-activating protein domain (GAP), suggesting its potential role in membrane trafficking. Insulin-stimulated phosphorylation of AS160 on threonine 642 is critical for mediating GLUT4 translocation in fat and muscle cells, via inactivation of Rab GAP function. Phosphorylation of threonine 642 is also important in mediating AS160 redistribution from low density microsomes to the cytosol in adipocytes.\n\nEpitope: DDPEKIEERKKSK\n\nApplications: \nSuitable for use in ELISA, Western Blotting. Other applications not tested.\n\nRecommended Dilution:\nELISA: antibody detection limit dilution 1:128,000. \nWestern Blot: 0.1-0.3ug/ml. ~150kD band observed in lysates of cell lines Daudi and MOLT4 (calculated MW of 147kD according to NP_055647.2). \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1124-53E

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in tris-saline [ pH7.3] with 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.Karlsson HK, Diabetes. 2005 Jun;54(6):1692-7. PMID: 15919790

Additional Info

Recognizes human TBC1D4.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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