AKT, total (AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA)

Supplier:

United States Biological

Cat no: 143131

AKT, total (AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA)

Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1)was originally identified as the oncogene in the transforming retrovirus, AKT8. Akt2 is an important signaling molecule in the Insulin signaling pathway. It is required to induce glucose transport. In a mouse which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth. In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. It has been reported that mice lacking Akt3 have small brains. \n\nApplications: \nSuitable for use in Western Blot. Other applications not tested. \n\nRecommended Dilution:\nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

143131

Size

100ul

Applications

WB

Hosts

Mouse

Reactivities

Mouse, Rat

Form

Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM NaCl, 0.2% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes endogenous levels of AKT. Does not cross-react with related proteins. Species Crossreactivity: mouse, rat

Alternative Names

(AKT, PKB, RAC, PRKBA, PKB-ALPHA, RAC-ALPHA)

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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