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AKT2, CT (RAC-beta Serine/Threonine-protein Kinase, Protein Kinase Akt-2, Protein Kinase B beta, PKB beta, RAC-PK-beta)

AKT2, CT (RAC-beta Serine/Threonine-protein Kinase, Protein Kinase Akt-2, Protein Kinase B beta, PKB beta, RAC-PK-beta)

Cat no: A1125-28P

Supplier: United States Biological
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The serine-threonine kinase Akt, also known as protein kinase B (PKB), is an important effector for phosphatidylinositol 3-kinase signaling initiated by numerous growth factors and hormones. Akt2/PKB beta, one of three known mammalian isoforms of Akt/PKB, has been demonstrated recently to be required for at least some of the metabolic actions. Over expression of exogenous Akt enhances cell survival by dramatically reducing apoptosis and transfection of dominant negative mutant kinase constructs (kinase-dead) inhibits survival of neurons promoted by IGF-1. Akt2 is also expressed in human carcinoma cell lines and primary tumors. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1125-28P
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Jones, P. et al. Proc Natl Acad Sci USA 88, 4171 (1991). 2. Bellacosa, A. et al. Science 254, 274 (1991). 3. Cho, H. et al. Science 292, 1728 (2001). 4. Yao, R. et al. Science 267, 2001 (1995).
Additional info: Recognizes human AKT2.

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