Home  >  Products  >  AKT2 (v-akt murine thymoma viral oncogene homolog 2, PKBB, PKBBETA, PKB beta, PRKBB, Protein kinase Akt-2, Protein kinase B beta, RAC-BETA, RAC-beta serine/threonine-protein kinase, RAC-PK-beta)
AKT2 (v-akt murine thymoma viral oncogene homolog 2, PKBB, PKBBETA, PKB beta, PRKBB, Protein kinase Akt-2, Protein kinase B beta, RAC-BETA, RAC-beta serine/threonine-protein kinase, RAC-PK-beta)

AKT2 (v-akt murine thymoma viral oncogene homolog 2, PKBB, PKBBETA, PKB beta, PRKBB, Protein kinase Akt-2, Protein kinase B beta, RAC-BETA, RAC-beta serine/threonine-protein kinase, RAC-PK-beta)

Cat no: A1125-25T

Supplier: United States Biological
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Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation. Applications: Suitable for use in ELISA, Western Blot and Immunofluorescence. Other applications not tested. Recommended Dilution: ELISA: 1:10,000 Western Blot: 1:500-1:2000 Immunofluorescence: 1:200-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1125-25T
Reactivities: Human, Rat, Non-Human Primate
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Western Blot
Size: 100ul
Form: Supplied as liquid, 0.04% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Ascites
References: 1. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E8-E15, 2. Oncol Rep. 2004 Jan;11(1):25-32, 3. Cancer Res. 2003 Jan 1; 63(1):196-206.
Additional info: Recognizes human AKT2 at 60kD. Species Crossreactivity: rat, monkey.

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