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Alarin (del/E3, Galanin-like Peptide, GALP)

Alarin (del/E3, Galanin-like Peptide, GALP)

Cat no: A1232-21B

Supplier: United States Biological
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Alarin is a hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2, and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. Isoform 2 exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2 (By similarity). Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A1232-21B
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a lyophilized powder. Reconstitute with sterile dH2O.
P type: Pab
Isotype: IgG
Purity: Purified
References: General References: 1. Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M., Kitada C., Kurokawa T., Onda H., Fujino M.; "Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus."; J. Biol. Chem. 274:37041-37045(1999). 2. Kofler B., Moritz K., Fenninger K.; "Differential splicing leads to the novel peptide alarin another member of the galanin-like peptide family." 3. Santic R., Fenninger K., Graf K., Schneider R., Hauser-Kronberger C., Schilling F.H., Kogner P., Ratschek M., Jones N., Sperl W., Kofler B.; "Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene."; J. Mol. Neurosci. 29:145-152(2006). 4. Santic R., Schmidhuber S.M., Lang R., Rauch I., Voglas E., Eberhard N., Bauer J.W., Brain S.D., Kofler B.; "Alarin is a vasoactive peptide."; Proc. Natl. Acad. Sci. U.S.A. 104:10217-10222(2007).
Additional info: Recognizes human Alarin.

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