Albumin, Human Serum (HSA)

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in this gene on chromosome 4 result in various anomalous proteins. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. The human albumin gene is 16,961 nucleotides long from the putative 'cap' site to the first poly(A) addition site. It is split into 15 exons which are symmetrically placed within the 3 domains that are thought to have arisen by triplication of a single primordial domain. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin.\n\nCellular Localization: Secreted\n\nApplications: \nSuitable for use in RID. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1274-87G

Size

1ml

Hosts

Sheep

Reactivities

Hum, Mouse, Rat, Bov, Can, Ch/Bird, Goat, GP, Prc, Rabbit

Form

Glycine buffered saline pH7.4, 0.1% EACA, 0.01% Benzamidine,1mM EDTA

P Type

Pab

Purity

Purified

Isotype

IgG

References

This product has been used in:Brantley JG et al. Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis. Kidney Int 63:1240-8 (2003).

Additional Info

This product gives a single arc when tested by IEP and 2D-IEP against human serum. Identity is confirmed by double diffusion (Ouchterlony) vs human plasma and a known anti-human albumin Species Crossreactivity: Crossreacts with Human, Rabbit, Rat, Horse, Mouse, Goat, bovine, canine, Pig, Cat, Guinea pig and Chicken. Not yet tested in other species.

Alternative Names

Allergen Bos d 6, HSA, PRO0883, PRO0903, PRO1341, PRO1708, PRO2044, PRO2619, PRO2675, Serum albumin precursor