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Aldo-Keto Reductase Family 1 Member C4 (AKR1C4, HGNC:387, 3-alpha-HSD, C11, CDR, CHDR, DD4, HAKRA, MGC22581, 3-alpha Hydroxysteroid Dehydrogenase Type I, 3 alpha-Hydroxysteroid Dehydrogenase, 3-alpha-Hydroxysteroid Dehydrogenase Variant, Chlordecone Reduc

Cat no: A1334-70T

Aldo-Keto Reductase Family 1 Member C4 (AKR1C4, HGNC:387, 3-alpha-HSD, C11, CDR, CHDR, DD4, HAKRA, MGC22581, 3-alpha Hydroxysteroid Dehydrogenase Type I, 3 alpha-Hydroxysteroid Dehydrogenase, 3-alpha-Hydroxysteroid Dehydrogenase Variant, Chlordecone Reduc

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.\n\nPositive Control: Human Liver lysate

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SPECIFICATIONS

Catalog Number

A1334-70T

Size

100ug

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-saline, pH7.2, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

Lord SJ, Mack WJ, Van Den Berg D, Pike MC, Ingles SA, Haiman CA, Wang W, Parisky YR, Hodis HN, Ursin G., Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study. ,Breast Cancer Res. 2005;7(3):R336-44. Epub 2005 Feb 23., PMID: 15987428

Additional Info

Species Crossreactivity: Human. Other species not tested.

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