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Alexa Fluor(R) 647 anti-human CD197 (CCR7)

Alexa Fluor(R) 647 anti-human CD197 (CCR7)

Cat no: 335604

Supplier: BioLegend
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CCR7 is a chemokine receptor that binds CCL19 and CCL21 (1). CCR7 and its ligands link innate and adaptive immunity through their effects on interactions between T cells and dendritic cells. Naive T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent (2). In addition, during immunological surveillance, B lymphocytes re-circulate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated to lymph node metastasis.
Catalogue number: 335604
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 tests
Clone: TG8/CCR7
Gene: 1236
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Isotype: Mouse IgG2a, kappa
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CCR7, BLR2, CDw197
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