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Alexa Fluor(R) 647 anti-human LAP (TGF-beta1)

Alexa Fluor(R) 647 anti-human LAP (TGF-beta1)

Cat no: 341801

Supplier: BioLegend
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TGF-beta1 (transforming growth factor beta1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many kinds of cells. Platelets express high level of TGF-beta. TGF-beta is synthesized as a large protein precursor and then secreted as a complex of TGF-beta and LAP (latency-associated peptide). TGF-beta requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-beta binds to the integrins alphavbeta1, alphavbeta6, alphavbeta8 and alpha8beta1 through RGD domain. TGF-beta plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-beta is believed to be important in regulation of the development of Treg, Th17, and Th9 cells. Recent study has shown that LAP is an activated Treg surface marker.
Catalogue number: 341801
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 25 tests
Clone: BG/hLAP
Gene: 7040
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Isotype: Mouse IgG1
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta, TGF-B1
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