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Alexa Fluor(R) 647 anti-mouse CD182 (CXCR2)

Alexa Fluor(R) 647 anti-mouse CD182 (CXCR2)

Cat no: 129101


Supplier: BioLegend
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CXCR2 is a 7-transmembrane G protein–coupled receptor that is activated by CXC chemokines containing the ELR (Glu-Leu-Arg) motif, including murine CXCL1 (keratinocyte-derived chemokine; KC) CXCL2 (macrophage inflammatory protein 2; MIP-2), CXCL3 (DC inflammatory protein-1; Dcip1) and CXCL5 (LIX). CXCR2 is expressed on neutrophils, keratinocytes, mast cells, eosinophils, macrophages, and lung endothelial cells (1-3). Homing of mast cell progenitors (MCps) to the mouse small intestine involves CXCR2, vascular cell adhesion molecule-1 (VCAM-1), and the interaction of alpha4beta7 integrin with mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) (4). In addition, CXCR2 regulates endothelial VCAM-1 expression, MCp migration and the levels of intraepithelial MC in the lung of aerosolized, antigen-challenged mice (5).
Catalogue number: 129101
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 25 microg
Clone: TG11/CXCR2
Gene: 12765
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.** Alexa Fluor(R) 647 is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) 647 dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: C6 rat glioma cell line transfected with mouse CXCR2, Met1-Leu359, Accession# P35343
Isotype: Rat IgG2a
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CD128b, IL-8RB, Type II IL-8 receptor
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