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Alexa Fluor(R) 647 anti-mouse CD218a (IL-18Ralpha)

Alexa Fluor(R) 647 anti-mouse CD218a (IL-18Ralpha)

Cat no: 132903

Supplier: BioLegend
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The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor alpha (IL-18Ralpha) and IL-18 receptor beta (IL-18Rbeta). IL-18Ralpha (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Ralpha is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Ralpha is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Ralpha together with IL-18beta to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.
Catalogue number: 132903
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 25 tests
Clone: BG/IL18Ra
Gene: 16182
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen: Mouse NS0-derived rmIL-18Ralpha extracellular domain
Isotype: Rat IgG1
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Il1rrp, Il18ralpha, Il18r1
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