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Alexa Fluor(R) 647 anti-mouse CD49d

Alexa Fluor(R) 647 anti-mouse CD49d

Cat no: 103613


Supplier: BioLegend
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CD49d is a 150 kD glycoprotein, also known as alpha4 integrin or VLA-4 alpha chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two beta chains, beta1 (CD29) or beta7, to form the VLA-4 (integrin alpha4beta1) or LPAM-1 (integrin alpha4beta7) complexes. CD49d plays a critical role in both adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin. The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10(MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4.
Catalogue number: 103613
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 25 microg
Clone: R1-2
Gene: 16401
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: AKR/Cum mouse spontaneous T lymphoma line TK1
Isotype: Rat IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: alpha4 integrin, VLA-4 alpha chain, integrin a4
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