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Alexa Fluor(R) 647 Anti-rat CD161

Alexa Fluor(R) 647 Anti-rat CD161

Cat no: 203110

Supplier: BioLegend
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CD161 molecules, known as NKR-P1, are a family of about 30 kD type II transmembrane C-type lectin-like receptors and are expressed on the cell membrane as disulphide-linked homodimer. Rat NKR-P1 receptors are primarily expressed on NK cells, a subset of T cells, dendritic cells, and activated monocytes. Carbohydrate antigens with GalNac and GlcNac moieties are the ligands for NKR-P1 molecules. CD161 receptors are thought to be involved in the regulation of NK and NKT cell function. Three rat NKR-P1 genes have been described, NKR-P1A, NKR-P1B, NKR-P1B*(or NKR-P1D). 10/78, similar like 3.2.3 antibody, recognizes a common epitope of NKR-1A (CD161a) and NKR-P1B (CD161b). NKR-P1A does not contain ITIM structure and is an activating receptor, while NKR-P1B contains an ITIM and displays an inhibitory function.
Catalogue number: 203110
Reactivities: Rat
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 100 microg
Clone: 10/78
Gene: 80782
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor(R) 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: LEW rat splenic NK cells
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: NKR-P1, CD161a/CD161b, NKR-P1A/NKR-P1B
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