ALK-7 (Activin Receptor-like Kinase 7, Activin RIC, ACVR1C, ACVRLK7) (APC)

Supplier:

United States Biological

Cat no: 145384

ALK-7 (Activin Receptor-like Kinase 7, Activin RIC, ACVR1C, ACVRLK7) (APC)

Transforming Growth Factor beta (TGF-b) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes consisting of two types (I and II) of serine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various Smad proteins. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGF-b superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors [also termed activin receptor like kinase (ALK)] and five type II receptors have been isolated from mammals. ALK2, 3, 4, 5, and 6 are also known as Activin R1A, BMPR1A, Activin R1B, TGF-b R1, and BMPR1B, respectively, reflecting their ligand preferences. ALK7 contains a cysteine-rich domain with conserved cysteine spacing in the extracellular region that is shared by other type I receptors, and a glycine-and-serine-rich domain (the GS domain) preceding the kinase domain.\n\nApplications: \nSuitable for use in Flow Cytometry and ELISA. Other applications not tested.\n\nRecommended Dilution: \nFlow Cytometry: 10ul, 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at 12 months at 4 degrees C. Freezing allophycocyanin conjugates will result in a substantial loss of activity. Allophycocyaninconjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

145384

Size

100Tests

Applications

ELISA, FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.5% BSA, 0.09% sodium azide. Labeled with Allophycocyanin (APC).

P Type

Mab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes human ALK-7.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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