Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Source:
Synthetic
Atmosphere:
Inert gas
Purity:
(same/more than)98%
Form:
Yellow Solid
Melting Point:
173-175 degrees C
Solubility:
Chloroform
Stability:
Light and temperature sensitive.
Method for Determining Identity:
Proton NMR Spectroscopic Analysis.
TLC Conditions:
SiO2: Hexane: Ethyl acetate:1:1; Visualized with UV and AMCS; Single spot; Rf=0.6.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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