Alpha-2C Adrenergic Receptor (ADRA2L2, ADRARL2, ALPHA2CAR)

The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C\nAdrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.\n\nApplications: \nWestern Blot and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\n1ug/ml was sufficient for detection of Alpha-2C Adrenergic Receptor in 20ug of COS cells transiently transfected with HA-tagged Alpha-2C membrane lysate and assayed by Western Blot using goat anti-mouse IgG:HRP as the secondary antibody.\nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

167571

Size

100ug

Applications

ICC, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS pH7.4, 50% glycerol.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2a

References

1. Filipeanu C.M., et al. (2011) Biochim BiophysActa. 1813: 346-357.\n2. Powe D.G., et al. (2011) Breast Cancer Res\nTreat. 130: 457-463.

Additional Info

Recognizes human Alpha-2C Adrenergic Receptor. Species Crossreactivity: Mouse, Human. Detects 50kD or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.