Home  >  Products  >  ALS2CR2, CT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)
ALS2CR2, CT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)

ALS2CR2, CT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)

Cat no: A1363-10N

Supplier: United States Biological
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ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 1-3ug/ml Immunohistochemistry (Formalin-fixed, paraffin-embedded): 3.75ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1363-10N
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human STRADB. Species sequence homology: canine

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