Home  >  Products  >  ALS2CR3 (GRIF 1, Amyotrophic Lateral Sclerosis 2 (juvenile) Chromosome Region, candidate 3, CALS-C, GRIF-1, KIAA0549, OIP98, Trafficking kinesin-binding protein 2, Trafficking protein, kinesin-binding 2)
ALS2CR3 (GRIF 1, Amyotrophic Lateral Sclerosis 2 (juvenile) Chromosome Region, candidate 3, CALS-C, GRIF-1, KIAA0549, OIP98, Trafficking kinesin-binding protein 2, Trafficking protein, kinesin-binding 2)

ALS2CR3 (GRIF 1, Amyotrophic Lateral Sclerosis 2 (juvenile) Chromosome Region, candidate 3, CALS-C, GRIF-1, KIAA0549, OIP98, Trafficking kinesin-binding protein 2, Trafficking protein, kinesin-binding 2)

Cat no: A1363-15A

Supplier: United States Biological
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Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, is connected to transferase/kinase activity and ATP binding, it has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A1363-15A
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. Genomics. 2001 Jan 15;71(2):200-13.
Additional info: Recognizes ALS2CR3.

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