Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1, ASPCR1, ASPL, ASPS, RCC17, TUG)

The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin. \n\nApplications:\nSuitable for use in Western Blot and ELISA. Other applications not tested. \n\nRecommended Dilution:\nWestern Blot: 1:500-1:2000 \nELISA: 1:10,000\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A1372-02A

Size

40ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide and 50% glycerol.

P Type

Mab

Purity

Purified immunoglobulin

References

Jonathan S.B, Natalie H, Adrienne E. Lodish Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 2003,425:727 - 733.

Additional Info

Recognizes human Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1, ASPCR1, ASPL, ASPS, RCC17, TUG).