ALY (K161) Peptide

ALY (also designated THO complex subunit 4, THOC4, REF1, Refbp1 and BEF) is the mammalian homolog of the yeast mRNA export factor Yralp. A transcriptional coactivator, ALY belongs to the cytidylyltransferase family and is important in mRNA processing and export. During spliceosome assemby, it is recruited to messenger ribonucleoprotein (mRNP) complexes and becomes tightly associated with the spliced mRNP. Consistent with splicing-dependent recruitment, ALY co-localizes with splicing factors in the nucleus. It promotes transcriptional activation by promoting the dimerization of transcription factors containing basic leucine zipper domains. Although ubiquitously expressed, ALY specifically associates with the activation domains of LEF-1 and AML-1, both of which are protein components of the TCR alpha enhancer complex. Research indicates that ALY may mediate context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR alpha enhancer complex.

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SPECIFICATIONS

Catalog Number

BS9250P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide ALY (K161). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q86V81

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS9250 ALY (K161) pAb.

Alternative Names

ALY; ALY/REF; Aly/REF export factor; BEF; bZIP enhancing factor; bZIP-enhancing factor BEF; REF; THO complex 4; THO complex subunit 4; Tho4; THOC 4; THOC-4; THOC4;