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AMI-1 (Arginine N-methyltransferase inhibitor-1)

Cat no: 044499


Supplier: United States Biological
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Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8 microM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0 microM). Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C.
Catalogue number: 044499
Size: 5mg
Purity: >99% (NMR)
Alternative names: Arginine N-methyltransferase inhibitor-1
References: Product Reference: ?Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) ?A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) ?Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009) ?

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