AMOT, phosphorylated (Y599) (AMOT, KIAA1071, Angiomotin)

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.\n\nApplications:\nSuitable for use in Dot Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nDot blot 1:500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

031849

Size

200ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Heller, B., et al. J. Biol. Chem. 285(16):12308-12320(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Gagne, V., et al. Cell Motil. Cytoskeleton 66(9):754-768(2009) Zheng, Y., et al. Circ. Res. 105(3):260-270(2009)

Additional Info

Human

Alternative Names

AMOT, KIAA1071, Angiomotin