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AMP Activated Protein Kinase alpha1 (AMPK a1)

AMP Activated Protein Kinase alpha1 (AMPK a1)

Cat no: A1475-01P4

Supplier: United States Biological
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AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilised by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels. AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells. Applications: Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:100-1:1,000. Detects a band of ~63kD in rat brain cell lysates. Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1475-01P4
Reactivities: Drosophila/Arthropod
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
Alternative names: 5 AMP activated protein kinase catalytic alpha 1 chain, 5' AMP activated protein kinase catalytic subunit alpha 1, AAPK1, AMPK alpha 1 chain, AMPK, AMPK1, AMPKa1, HMG CoA reductase kinase, MGC33776, MGC57364, PRKAA 1, PRKAA1, Protein kinase AMP activated alpha 1 catalytic subunit, Acetyl CoA carboxylase kinase, Hormone sensitive lipase kinase, Kinase AMPK alpha1
Additional info: Recognizes both the alpha 1 and the alpha 2 isoforms of Drosophila AMP-activated protein kinase (AMPK). Species sequence homology: vertebrates, human, mouse, rat.

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