Home  >  Products  >  AMP Activated Protein Kinase beta1 (AMPK beta-1 Chain, AMPK Subunit beta-1, AMPK b1, AMPKb, 5'-AMP-activated Protein Kinase Subunit beta-1, HAMPKb, MGC17785, PRKAB1)
AMP Activated Protein Kinase beta1 (AMPK beta-1 Chain, AMPK Subunit beta-1, AMPK b1, AMPKb, 5'-AMP-activated Protein Kinase Subunit beta-1, HAMPKb, MGC17785, PRKAB1)

AMP Activated Protein Kinase beta1 (AMPK beta-1 Chain, AMPK Subunit beta-1, AMPK b1, AMPKb, 5'-AMP-activated Protein Kinase Subunit beta-1, HAMPKb, MGC17785, PRKAB1)

Cat no: A1475-03

Supplier: United States Biological
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AMPK beta-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: ELISA: 0.25ug/ml Western Blot: 0.5-2.5ug/ml Immunohistochemistry: 2.5-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1475-03
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G afinity chromatography.
Alternative names: Protein Kinase, AMP-activated, beta 1 Non-catalytic Subunit
References: 1.Minokoshi, Y., et al., Nature 428(6982):569-574 (2004). 2.Andersson, U., et al., J. Biol. Chem. 279(13):12005-12008 (2004). 3.Landree, L.E., et al., J. Biol. Chem. 279(5):3817-3827 (2004). 4.Carling, D., Trends Biochem. Sci. 29(1):18-24 (2004). 5.Shaw, R.J., et al., Proc. Natl. Acad. Sci. U.S.A. 101(10):3329-3335 (2004).
Additional info: Recognizes human AMPK beta. Species crossreactivity: mouse.

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